Larval development on ivermectin aglycone plates.

<p>Larval development assays were undertaken for all lines, at pre- and post-treatment timepoints, in the third generation of selection. (A) Control (CTL) lines had no treatment applied but sampling was time-matched with the selected lines ((B) IVM = ivermectin and (C) MOX = moxidectin). Y axi...

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Bibliografische gegevens
Hoofdauteur:	Jennifer McIntyre (6237104) (author)
Andere auteurs:	Alison Morrison (183550) (author), Kirsty Maitland (364090) (author), Eileen Devaney (364093) (author), James A. Cotton (7410761) (author), Collette Britton (4598638) (author), Ray M. Kaplan (7410758) (author), Dave Bartley (20685053) (author), Roz Laing (183493) (author)
Gepubliceerd in:	2025
Onderwerpen:	Microbiology Cell Biology Genetics Pharmacology Biotechnology Evolutionary Biology Ecology Cancer Hematology Infectious Diseases Plant Biology Virology Computational Biology ‘ underdosing ’ lack genetic markers incoming helminth populations acting macrocyclic lactone three subtherapeutic treatments monitor emerging resistance haemonchus contortus </ prior ivermectin exposure shared genetic locus macrocyclic lactone resistance chromosome v locus ivermectin resistance manifesting moxidectin resistance haplotypes moxidectin resistance appears single subtherapeutic dose div >< p shared locus chromosome v macrocyclic lactones moxidectin resistance subtherapeutic treatment underlying resistance resistance within resistance phenotype anthelmintic resistance vivo </ vitro </ subtherapeutic selection equivalent ivermectin subsequent doses selected lines parasitic helminths naïve population moxidectin selection increasing reliance increasing doses half dose full standard findings highlight extended half dominant trait common problem
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Larval development on ivermectin aglycone plates.

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