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<div><p>Cyclic adenosine monophosphate (cAMP), a ubiquitous second messenger, regulates a variety of cellular functions with high specificity. We previously showed that the type I regulatory subunit of cAMP-dependent protein kinase A (PKA), RIα, undergoes liquid–liquid phase separation (...

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التفاصيل البيبلوغرافية
المؤلف الرئيسي:	Ha Neul Lee (7360352) (author)
مؤلفون آخرون:	Julia C. Hardy (21781692) (author), Emily H. Pool (14883318) (author), Jin-Fan Zhang (21781695) (author), Su Hyun Kim (828853) (author), William F. Buhl (21781698) (author), Jessica G.H. Bruystens (21781701) (author), Sohum Mehta (2000764) (author), Susan S. Taylor (44167) (author), Jin Zhang (53297) (author)
منشور في:	2025
الموضوعات:	Biochemistry Microbiology Cell Biology Genetics Molecular Biology Physiology Developmental Biology Cancer Virology Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified ubiquitous second messenger selective molecular tool reveal key roles prevent uncontrolled proliferation min6 β cells mediated gene expression facilitate spatial compartmentalization dependent protein kinase cyclic adenosine monophosphate control insulin secretion based riα knockout exhibits defective camp camp oscillation frequency div >< p 2 +</ sup studying riα llps pka ), riα camp ), riα mutant riα llps riα condensates regulatory subunit regulate creb previously showed pka type phase separation largely unknown induced llps high specificity functional impact data establish combining crispr cellular functions
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