Representative scheme of the downstream signaling upon LD-S vs LD-R infection at 4 hrs and 24 hrs pi.

<p>At 4 hrs pi (left panel), LD-R triggers ROS production which promotes nuclear translocation of p50 and c-Rel. p50/c-Rel binds to the promoter of Heme-oxygenase 1 and activates it. HO-1 protein catalyzes the breakdown of heme into iron (Fe<sup>2+</sup>). LD-R reshuffles Ferroport...

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محفوظ في:

التفاصيل البيبلوغرافية
المؤلف الرئيسي:	Souradeepa Ghosh (14276657) (author)
مؤلفون آخرون:	Krishna Vamshi Chigicherla (20649145) (author), Shirin Dasgupta (20649148) (author), Yasuyuki Goto (22965) (author), Budhaditya Mukherjee (106862) (author)
منشور في:	2025
الموضوعات:	Biochemistry Medicine Microbiology Cell Biology Biotechnology Evolutionary Biology Ecology Inorganic Chemistry Hematology Infectious Diseases Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified unresponsiveness points towards treating visceral leishmaniasis sustaining heightened levels selectively reshuffling macrophage recent clinical isolates leishmania donovani </ inherent metabolic shift even though anti div >< p surface iron exporter subsequent iron insufficiency higher iron utilization triggering oxidative outburst gained increased potential withstand elevated ros elevated ros levels pv thereby gaining pentavalent antimonials relies surplus iron iron within oxidative stress increased erythrophagocytosis two proteases survival edge surprising strategy study highlights sensitive counterparts parasitophorous vacuoles leishmanial activity intracellular pathogens infected macrophages genetic adaptation evolutionary persistence complex interplay cd47 surveillance aggressive proliferation
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Representative scheme of the downstream signaling upon LD-S vs LD-R infection at 4 hrs and 24 hrs pi.

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