Enantioselective Synthesis of N–N Indole-Pyrrole Atropisomers via Palladium/Chiral Phosphonic Acid Relay Catalysis

N–N atropisomers have emerged as indispensable structural motifs in natural products, medicinal chemistry, and asymmetric catalysis due to their unique stereochemical properties. Herein, we introduce an innovative synthetic methodology for the enantioselective construction of N–N indole-pyrrole atro...

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Bibliografiset tiedot
Päätekijä:	Dayuan Wang (11675024) (author)
Muut tekijät:	Jiayi Zong (17899433) (author), Boxuan Zhang (9577256) (author), Jiahao Wang (4710915) (author), Bowen Wang (526637) (author), Huri Piao (21685454) (author), Dang Cheng (4111618) (author), Jinfei Lin (837828) (author), Zhiran Ju (11431017) (author), Miaolin Ke (2600278) (author), Fener Chen (1491025) (author)
Julkaistu:	2025
Aiheet:	Biochemistry Microbiology Molecular Biology Pharmacology Biotechnology Ecology Immunology Environmental Sciences not elsewhere classified Chemical Sciences not elsewhere classified unique stereochemical properties innovative synthetic methodology indispensable structural motifs demonstrate potent anti chiral phosphonic acid biological evaluation revealed asymmetric catalysis due 3bi </ b relay catalysis n </ ee </ stimulated raw264 pyrrole atropisomers natural products medicinal chemistry inflammatory activity exceptional enantiocontrol excellent yields enantioselective synthesis enantioselective construction efficient synthesis >- amino 92 %) 7 macrophages
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Enantioselective Synthesis of N–N Indole-Pyrrole Atropisomers via Palladium/Chiral Phosphonic Acid Relay Catalysis

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