Effect size distribution and intersections of transcript usage response upon stimulation with M. leprae sonicate by T1R-free (LEP) and T1R-destined (T1R) leprosy patients.

(A) Strip plot presenting the distribution of the mean fitted proportion difference (PΔ) between stimulated and non-stimulated samples by group. Transcripts represented by dots were ordered along the x-axis according to increasing PΔ values for the LEP group. Light gray d...

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التفاصيل البيبلوغرافية
المؤلف الرئيسي:	Wilian Correa-Macedo (11813183) (author)
مؤلفون آخرون:	Monica Dallmann-Sauer (8856518) (author), Marianna Orlova (238676) (author), Jeremy Manry (416339) (author), Vinicius M. Fava (8856524) (author), Nguyen Thu Huong (10232520) (author), Nguyen Ngoc Ba (10232523) (author), Nguyen Van Thuc (288133) (author), Vu Hong Thai (8856521) (author), Erwin Schurr (238686) (author)
منشور في:	2024
الموضوعات:	Microbiology Cell Biology Genetics Immunology Developmental Biology Computational Biology Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified whole blood aliquots peripheral nerves caused go terms involved significantly higher upregulation major public health div >< p peripheral blood cells mycobacterium leprae </ transcript expression suggested t1r patients displayed 32 leprosy patients symptoms </ p transcriptomic immune response leprae </ transcriptomic response transcriptome immune t1r symptoms significantly different major focus differential transcript leprosy patients 22 patients 10 patients vitro </ year follow total rna reversal reactions results showed remained t1r regulatory differences prospective study prevent t1r often contribute nerve damage microbiological cure main difference leprosy reactions intracellular pathogens inflammatory processes inflammatory episodes early intervention developed t1r collected samples clinical problem chronic disease apoptosis regulation analysis focused
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Effect size distribution and intersections of transcript usage response upon stimulation with <i>M</i>. <i>leprae</i> sonicate by T1R-free (LEP) and T1R-destined (T1R) leprosy patients.

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