Binding affinity of Akt1/Akt2-IN-1, Capivasertib, and Ipatasertib with AKT2 (wild and mutants) protein.

<p>Binding affinity of Akt1/Akt2-IN-1, Capivasertib, and Ipatasertib with AKT2 (wild and mutants) protein.</p>

محفوظ في:

التفاصيل البيبلوغرافية
المؤلف الرئيسي:	Sadia Afrin Runa (22504971) (author)
مؤلفون آخرون:	Mahafujul Islam Quadery Tonmoy (11241774) (author), Md. Ashiqul Islam (22504974) (author), Md. Aminul Islam (6750650) (author)
منشور في:	2025
الموضوعات:	Biophysics Biochemistry Medicine Genetics Pharmacology Cancer Infectious Diseases Virology Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified single nucleotide polymorphisms mutations may contribute molecular docking revealed increased residue flexibility including metal binding flexible binding pocket decreased binding affinity akt signaling pathway targeted cancer therapies optimizing cancer treatment pronounced destabilizing effect functionally significant nssnps div >< p weakening inhibitor interactions reduced inhibitor binding impact protein structure inhibitor interactions cancer remains reduced efficacy inhibitor resistance inhibitor complex tumor progression translational modifications three structurally therapy resistance terminal domain study underscores r467wwere found protein instability potential drivers mortality worldwide md simulations kinase domain kinase c key kinase hydrogen bonds genetic screening functional consequences findings suggest critical role computational evaluation allosteric sites
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