Increased efficiency of CD4 use in HIV-1 transfer between infected T cells and MDMs.

A) The experiments analyzing CD4 dependence were performed with similar proportion of Gag+ MDMs exposed to cell-free (CF) JR-FL Env-pseudotyped viruses or Jurkat cells infected with JR-FL (FL) or JR-CSF (CSF) Env-pseudotyped viruses (CTC). B) Dose-depen...

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Bibliographic Details
Main Author:	Mingyu Han (117419) (author)
Other Authors:	Vincent Cantaloube-Ferrieu (10668489) (author), Maorong Xie (12667266) (author), Marie Armani-Tourret (6057515) (author), Marie Woottum (12667269) (author), Jean-Christophe Pagès (3185709) (author), Philippe Colin (128052) (author), Bernard Lagane (51657) (author), Serge Benichou (66775) (author)
Published:	2022
Subjects:	Medicine Microbiology Cell Biology Immunology Cancer Infectious Diseases Virology Biological Sciences not elsewhere classified receptor expression levels viral transfer proceeded div >< p cell spread overcomes cell count declines cell transfer overcomes isolates initially defined cxcr4 entry receptors cell viral transfer free viral particles virus entry block cell rich tissues infection assays suggest macrophages </ p viral entry cell transfer entry block virus isolates free particles virus cell initially suggested cxcr4 usage vivo </ vitro </ effectively cell dependent cell cell transferred cell paucity cell fusion free mode free infection sheds light results show reduced dependence prevalent tropism late stage increasingly recognized including transmitted fully reflect different stages current view
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Increased efficiency of CD4 use in HIV-1 transfer between infected T cells and MDMs.

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