IFN-I signaling proteins are activated in HAND brains.

<p>IFN-I signaling proteins were up-regulated in the WM of HAND brains. The normalized Z-scores of the proteins in HAND brains (n = 14) were compared with that of the HIV- control brain samples (n = 3) or to HIV+HAND- brains (n = 3). The p-value was calculated with the Brown-Forsythe Welch ANO...

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Автор:	Yuyang Tang (124043) (author)
Інші автори:	Ling Xie (2026981) (author), Ciniso Sylvester Shabangu (18236013) (author), Dajiang Li (3819199) (author), Gabriela da Silva Prates (15229642) (author), Ashokkumar Manickam (22097256) (author), Lilly M. Wong (12221774) (author), Antoine Chaillon (309416) (author), Edward P. Browne (8913893) (author), Sara Gianella (196115) (author), Wenzhe Ho (332788) (author), David M. Margolis (244046) (author), Xian Chen (107385) (author), Wenhui Hu (80326) (author), Guochun Jiang (777612) (author)
Опубліковано:	2025
Предмети:	Biophysics Cell Biology Genetics Molecular Biology Neuroscience Physiology Immunology Developmental Biology Cancer Mental Health Infectious Diseases Biological Sciences not elsewhere classified present &# 8212 last gift cohort increased &# 8212 human endogenous retrovirus cell rna sequencing 7 %&# 8212 associated neurocognitive disorders also highly active happen without hiv brain tissues collected brain organoid model acute hiv infection immune response pathways glial cells even interferon signaling within remains active endothelial cells cognitive disorders xlink "> using single unrelated mechanisms rapid autopsies protein profiles negative controls molecular mechanism may contribute hand ), findings point especially strong directly trigger better understand antiretroviral therapy 9 hand 27 brains
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IFN-I signaling proteins are activated in HAND brains.

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