Thiol-Epoxy Click Chemistry: Neutral Quaternary Phosphonium-Promoted Weak Catalysis for Alkylation of Thiols

Thiol-Epoxy Click Chemistry: Neutral Quaternary Phosphonium-Promoted Weak Catalysis for Alkylation of Thiols

The thiol-involved ring-opening reaction of epoxides plays a critical role in organic synthesis and life sciences. However, achieving efficient, precise, and green thiolysis of epoxides under mild conditions remains a significant challenge, and the application in thiol-targeted alkylation in biologi...

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Bibliographic Details
Main Author: Silei Ye (15425692) (author)
Other Authors: Fang Zhang (197215) (author), Jing Zhao (21160) (author), Yunji Yang (22662742) (author), Yanren Zhu (15425686) (author), Mengxian Yang (22662745) (author), Yushun Zhang (734479) (author), Dongbo Zhao (577120) (author), Hongbin Zhang (258308) (author), Jingbo Chen (574291) (author)
Published: 2025
Subjects:
Biophysics
Biochemistry
Molecular Biology
Pharmacology
Biotechnology
Infectious Diseases
Chemical Sciences not elsewhere classified
synergistic catalytic process
sup >–</ sup
promoted weak catalysis
phosphonium ion coordinates
neutral quaternary phosphonium
neutral phosphonium salts
epoxy click chemistry
enabled catalyst recycling
density functional theory
narrow substrate scope
mild conditions remains
method demonstrated scalability
>- scale synthesis
harsh reaction conditions
leverage thiol alkylation
substrate compatibility
opening reaction
method provides
harsh acidic
basic conditions
ambient conditions
organic synthesis
drug synthesis
work validates
transition metals
toxic reagents
thiol deprotonation
targeted alkylation
straightforward thiol
significant challenge
seven cycles
quantitative conversion
peptide conjugations
life sciences
involved ring
hydroxy thioethers
green thiolysis
green platform
g </
drug precursors
critical role
consistent efficiency
challenging substrates
calculations reveal
biomolecular modifications
biological scenarios
aqueous systems
achieving near
achieving efficient
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