Thiol-Epoxy Click Chemistry: Neutral Quaternary Phosphonium-Promoted Weak Catalysis for Alkylation of Thiols

The thiol-involved ring-opening reaction of epoxides plays a critical role in organic synthesis and life sciences. However, achieving efficient, precise, and green thiolysis of epoxides under mild conditions remains a significant challenge, and the application in thiol-targeted alkylation in biologi...

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التفاصيل البيبلوغرافية
المؤلف الرئيسي:	Silei Ye (15425692) (author)
مؤلفون آخرون:	Fang Zhang (197215) (author), Jing Zhao (21160) (author), Yunji Yang (22662742) (author), Yanren Zhu (15425686) (author), Mengxian Yang (22662745) (author), Yushun Zhang (734479) (author), Dongbo Zhao (577120) (author), Hongbin Zhang (258308) (author), Jingbo Chen (574291) (author)
منشور في:	2025
الموضوعات:	Biophysics Biochemistry Molecular Biology Pharmacology Biotechnology Infectious Diseases Chemical Sciences not elsewhere classified synergistic catalytic process sup >–</ sup promoted weak catalysis phosphonium ion coordinates neutral quaternary phosphonium neutral phosphonium salts epoxy click chemistry enabled catalyst recycling density functional theory narrow substrate scope mild conditions remains method demonstrated scalability >- scale synthesis harsh reaction conditions leverage thiol alkylation substrate compatibility opening reaction method provides harsh acidic basic conditions ambient conditions organic synthesis drug synthesis work validates transition metals toxic reagents thiol deprotonation targeted alkylation straightforward thiol significant challenge seven cycles quantitative conversion peptide conjugations life sciences involved ring hydroxy thioethers green thiolysis green platform g </ drug precursors critical role consistent efficiency challenging substrates calculations reveal biomolecular modifications biological scenarios aqueous systems achieving near achieving efficient 10 -<
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Thiol-Epoxy Click Chemistry: Neutral Quaternary Phosphonium-Promoted Weak Catalysis for Alkylation of Thiols

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