Identification of melanoma brain metastasis-associated tumor cell subpopulations (MBMATCs).

<p>(A) Melanoma tumor cell subtype classification from integrated scRNA-seq and snRNA-seq data. Circular plot depicts tissue origins across ten subtypes. (B) Copy number variation (CNV) scores in melanoma subtypes versus reference cells (Macrophage and T/NK cells). Significance levels: P < ...

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Autore principale:	Jingxin Zeng (18773484) (author)
Altri autori:	Ling Lin (57361) (author), Yangyang Ma (6329852) (author), Wenzhe Huang (446343) (author), Quan Luo (1423180) (author), Ju Wen (14784239) (author)
Pubblicazione:	2025
Soggetti:	Cell Biology Genetics Neuroscience Biotechnology Immunology Developmental Biology Cancer Hematology Virology Biological Sciences not elsewhere classified Information Systems not elsewhere classified limited treatment efficacy associated tumor cells adhesion genes (< nucleus rna sequencing metastatic tumor subpopulation 26 melanoma samples study identifies mbmatcs mbm ecosystems showed div >< p melanoma brain metastasis metastatic pathways bulk rna brain metastasis melanoma patients validation cohorts upregulated neural treg enrichment remains lethal potential activity nrg3 </ ncam1 </ mela3 ). lag3 </ high risk havcr2 </ early stratification clinical relevance cellular origins cellular origin brain tropism >), suggesting 1 </
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Identification of melanoma brain metastasis-associated tumor cell subpopulations (MBMATCs).

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