Role of N mRNA m6A modifications in RNA stability and efficient viral replication.

<p>(A) Schematic representation of the N gene with mutations to substitute the critical A, C, or T in the m6A motif. The m6A motif, the putative N6 adenosine, and the mutation sites are indicated by yellow squares, cyan, and red characters, respectively. (B) 293T cells were transfected with wt...

Fuld beskrivelse

Saved in:

Bibliografiske detaljer
Hovedforfatter:	Takashi Okura (7213349) (author)
Andre forfattere:	Yusuke Nakai (727708) (author), Taichi Kameya (21553628) (author), Fuminori Mizukoshi (374761) (author), Hiyori Okura (22756262) (author), Masatoshi Kakizaki (6167093) (author), Fumihiro Kato (5332957) (author), Yusuke Matsumoto (114541) (author), Yuichiro Nakatsu (498528) (author), Kaoru Takeuchi (431288) (author), Hirokazu Kimura (296843) (author), Makoto Takeda (296833) (author), Noriyuki Otsuki (498527) (author), Kazuya Shirato (6855140) (author), Hideki Hasegawa (249991) (author), Akihide Ryo (244201) (author)
Udgivet:	2025
Fag:	Biochemistry Medicine Microbiology Cell Biology Genetics Molecular Biology Evolutionary Biology Ecology Immunology Cancer Mental Health Infectious Diseases Plant Biology Virology Biological Sciences not elsewhere classified xlink "> n6 using reverse genetics identifying potential targets compromised antiviral responses viral life cycle rescue experiments demonstrated m6a site mutant m6a acceptor sites diminished interferon expression suppress host immunity driven mettl3 relocalization viral gene expression viral matrix protein mrna m6a modification viral titer viral replication viral propagation results demonstrated protein expression thereby advancing study illuminates significantly enhancing paramyxoviruses utilize methyltransferase domain mediated depletion host interactions epitranscriptomic marks environment conducive dual regulation dependent pathway critical role concomitant genome antigenome synthesis
Tags:	Tilføj Tag Ingen Tags, Vær først til at tagge denne postø!

Role of N mRNA m6A modifications in RNA stability and efficient viral replication.

Lignende værker