In silico modeling of potential key amino acid positions for the functional activity of mammalian CYP4B1.

(A) Multiplexed comparison of CYP4B1 amino acid sequences to identify hot spots with potential impact on catalytic function. Human-based amino acid exchanges are colored in blue, while substitutions in apes are colored in green. (B) The location of all...

সম্পূর্ণ বিবরণ

সংরক্ষণ করুন:

গ্রন্থ-পঞ্জীর বিবরন
প্রধান লেখক:	Saskia Hüsken (21616072) (author)
অন্যান্য লেখক:	Annika Röder (21616075) (author), Johannes Ptok (9283781) (author), Anne E. Meyer (21616078) (author), Mats Georg (21380052) (author), Yannick Schwarz (21616081) (author), Christian Roos (141269) (author), Kerstin Mätz-Rensing (365237) (author), Michael C. Hutter (2372869) (author), Doreen M. Floss (21616084) (author), Allan E. Rettie (219933) (author), Marco Girhard (3400892) (author), Helmut Hanenberg (140467) (author), Constanze Wiek (140463) (author)
প্রকাশিত:	2025
বিষয়গুলি:	Biochemistry Microbiology Genetics Molecular Biology Neuroscience Evolutionary Biology Infectious Diseases Virology Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified exon deletion found closely related species 14 primate genera human liver cells hydroxylate lauric acid amino acid analysis div >< p native human cyp4b1 tested cyp4b1 orthologs lauric acid cyp4b1 orthologs human evolution human enzymes functional analysis also tested inactivating cyp4b1 gorilla cyp4b1 cyp4b1 inactivation cyp4b1 enzymes v71g specific ultimately improve perilla ketone negative impact genetic changes evolutionary trigger endobiotic substrates coli </ clear indication
ট্যাগগুলো:	ট্যাগ যুক্ত করুন কোনো ট্যাগ নেই, প্রথমজন হিসাবে ট্যাগ করুন!

<i>In silico</i> modeling of potential key amino acid positions for the functional activity of mammalian CYP4B1.

অনুরূপ উপাদানগুলি