Expression kinetics of hydrocephalus-related genes and EPC-fate regulators in the bifurcating trajectory.

(A) The five causative hydrocephalus genes were up-regulated specifically in the nEPC branch. (B) Heatmap demonstrating 86 genes that have mutations in hydrocephalus were specifically upregulated in the nEPC branch. (C) Heatmap showin...

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Autor principal:	Jianqun Zheng (21820181) (author)
Altres autors:	Yawen Chen (1745545) (author), Yukun Hu (427264) (author), Yujian Zhu (16837967) (author), Jie Lin (119522) (author), Manlin Xu (4730613) (author), Yunlong Zhang (112004) (author), Weihong Song (436487) (author), Xi Chen (35903) (author)
Publicat:	2025
Matèries:	Cell Biology Genetics Neuroscience Developmental Biology Cancer Hematology Computational Biology Biological Sciences not elsewhere classified targeted clinical drugs several transcription factors offer novel insights novel intermediate state molecular mechanisms guiding largest neurogenic niche di &# 64256 continuous bifurcating trajectory adult mammalian brain radial glial cells neural stem cells marker genes simultaneously multiciliated ependymal cells tfeb activation prevents nsc branch unveiled cell fate commitment ependymal cells related genes fate determinants cell resolution xlink "> ventricular zone tune nsc transcriptomic dynamics results resolve related disorders potential application neurodegenerative diseases nepcs forms nepcs ). master regulator many multicilia lysosome biogenesis lineage trajectories dynamic repertoire canonical function analysis along
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Expression kinetics of hydrocephalus-related genes and EPC-fate regulators in the bifurcating trajectory.

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