Discovery of a Novel COS/H<sub>2</sub>S‑Donor Hybridized sGC Stimulator for Alleviating Isoproterenol-Induced Myocardial Fibrosis

Myocardial fibrosis contributes to heart failure (HF) progression, which is associated with impaired nitric oxide (NO)–soluble guanylyl cyclase (sGC)–cyclic guanosine monophosphate (cGMP) signaling. Hydrogen sulfide (H<sub>2</sub>S), a cardioprotective gasotransmitter, is reduced in pati...

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التفاصيل البيبلوغرافية
المؤلف الرئيسي:	Yi Yang (116183) (author)
مؤلفون آخرون:	Jiafei Wu (7456868) (author), Gongyun He (22233505) (author), Siqi Yao (3798133) (author), Li-Yuan Wei (13602413) (author), Quan Wang (31224) (author), Wei Dai (95957) (author), Han Yuan (521987) (author), Jianwen Chen (2211184) (author), Xiaoying Wang (30853) (author), Lei Guo (36221) (author)
منشور في:	2025
الموضوعات:	Biochemistry Cell Biology Genetics Physiology Pharmacology Developmental Biology Cancer Chemical Sciences not elsewhere classified transforming growth factor therapeutic options targeting impaired nitric oxide enhancement remain limited histological findings revealed novel carbonyl sulfide </ b >, 2 </ sub cos )/ h </ b novel cos hydrogen sulfide findings indicate sgc activation releasing property heart failure characterized h cardioprotective gasotransmitter beta 1 antifibrotic effects
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Discovery of a Novel COS/H<sub>2</sub>S‑Donor Hybridized sGC Stimulator for Alleviating Isoproterenol-Induced Myocardial Fibrosis

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