Connected components of significantly dysregulated metabolites.

Connected components of significantly dysregulated metabolites.

<p>The metabolite-centric network was reconstructed from the perturbed reactions in T2DM. Insignificant enriched metabolites were removed from the network. The two biggest connected components were found. The right component mainly consists of amino acids. The left component comprises metaboli...

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Bibliographic Details
Main Author: Maryam Khoshnejat (9294122) (author)
Other Authors: Ali Mohammad Banaei-Moghaddam (4371640) (author), Ali Akbar Moosavi-Movahedi (313649) (author), Kaveh Kavousi (5879501) (author)
Published: 2023
Subjects:
Biochemistry
Cell Biology
Genetics
Physiology
Cancer
Virology
Computational Biology
Biological Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
Information Systems not elsewhere classified
system biology approach
personalized metabolic modeling
newly diagnosed patients
machine learning method
blood sugar homeostasis
understanding metabolism reprogramming
pathways possibly interrupts
muscle metabolic reprogramming
specific metabolic model
13 exchange metabolites
develops insulin resistance
insulin resistance
muscle metabolism
glucose homeostasis
several pathways
dysfunctional metabolism
major insulin
discriminating insulin
skeletal muscle
resistant muscle
human muscle
signaling process
sensitive tissue
results indicated
pivotal role
mainly implicating
lipids metabolisms
holistic view
first reconstructed
extracellular matrix
ecm ).
early stage
early diagnosis
building membrane
amino acids
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