Interplay of APA and hsa-let-7a in regulating AURKA expression.

(A) Distribution of r coefficients of the AURKA protein-SLR correlation across cancers. p<0.05 only for BRCA. (B) Scatter plot showing cancers according to the cancer/normal AURKA SLR fold change and to the value of the ‘protein vs SLR’ correlation c...

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Bibliographic Details
Main Author:	Roberta Cacioppo (20160718) (author)
Other Authors:	Deniz Rad (20160721) (author), Giulia Pagani (12886199) (author), Paolo Gandellini (3665059) (author), Catherine Lindon (5309234) (author)
Published:	2024
Subjects:	Biophysics Biochemistry Cell Biology Genetics Molecular Biology Immunology Hematology Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified two alternative cleavage respective healthy counterparts prominent association exists cancer genome atlas 18 cancer types div >< p increased aurka mrna altered aurka levels controlling aurka expression aurka mrna aurka levels aurka expression cancer compared varying extents transcriptional regulation transcriptional control tcga ). study confirmed protein expression oncogenic activity omics data often discordant normal tissues measured differences major regulator long ratio likely involved highly dependent high expression general trend clustering analyses cell cycle aurora kinase 7a </
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Interplay of APA and <i>hsa-let-7a</i> in regulating AURKA expression.

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