The abundance of certain lipid families differs between the heads of injured and uninjured flies over time after TBI.

The abundance of certain lipid families differs between the heads of injured and uninjured flies over time after TBI.

<p>Heat maps of lipid class levels over time after TBI. Lipidomic analysis of heads was performed at 1, 7, 14, and 21 days post-injury of 7-day old, male, <i>w</i><sup><i>1118</i></sup> flies. <b>(A)</b> Each box represents the log<sub>2<...

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Bibliographic Details
Main Author:	Stacey A. Rimkus (2684350) (author)
Other Authors:	Barry Ganetzky (580420) (author), David A. Wassarman (9503999) (author)
Published:	2025
Subjects:	Biochemistry Cell Biology Genetics Neuroscience Physiology Sociology store neutral lipids species typically stored seven days post revealed elevated levels drosophila melanogaster </ 21 days post 14 days post ld modulatory factors ld formation post disrupting lipid homeostasis traumatic brain injury injury showed increases deleterious outcomes observed baseline levels observed limited lipid availability uninjured flies showed ld number occurred div >< p uninjured flies ld size ld number lipid toxicity lipid droplets glucose availability injured flies flies fed – organelles remained stable provide energy protective response protect cells potentially underlying oxidative stress one day number returned neurodegenerative disorders mitochondrial dysfunction may contribute marked increase lipidomic analysis fly brains findings suggest findings indicate dependent production dependent manner confocal microscopy
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