STAB1 or STAB2 expression increases THP-1 phagocytotic uptake of HLA-E coated beads (A) THP-1 dCas9 cells were transduced with a control guide or a guide targeting either LILRB1, STAB1 or STAB2 stained with HLA tetramers and analysed by flow cytometry.

<p>(B) THP-1 cells were incubated with HLA-E (VLA) coated microbeads at either 37°C or 4°C and analysed by flow cytometry. (C) THP-1 cells were incubated with fluorescent microbeads coated with peptide-loaded HLA molecules for either 1h or 24h and analysed using flow cytometry. The percentage...

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Bibliographic Details
Main Author:	Tom A. W. Schoufour (22421454) (author)
Other Authors:	Linda Voogd (20466968) (author), Kees L.M.C. Franken (14983373) (author), Tom H.M. Ottenhoff (11686365) (author), Ruud H.M. Wijdeven (22421457) (author), Simone A. Joosten (11074623) (author)
Published:	2025
Subjects:	Biochemistry Cell Biology Immunology Infectious Diseases Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified mycobacterium tuberculosis </ communicates cellular health cas9 activation screen low affinity peptides also present peptides identify additional hla e coated microbeads two novel hla div >< p 2 </ p peptides derived novel interactors specific hla stabilin receptors results provide natural killer leader sequence inhibit phagocytosis identified stabilin first evidence e tetramers e receptors e complex canonical role
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STAB1 or STAB2 expression increases THP-1 phagocytotic uptake of HLA-E coated beads (A) THP-1 dCas9 cells were transduced with a control guide or a guide targeting either LILRB1, STAB1 or STAB2 stained with HLA tetramers and analysed by flow cytometry.

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