Induction of cytochrome P450 expression in human cryopreserved hepatocytes (cryoheps).

<p>Cryoheps were cultured in the HM or HM Dex (-) media with inducer for 48 h from day 2 after seeding. Polystyrene and InnoCell plates were used for the culture. RNA was collected from the cells at the endpoint and analyzed by qPCR. The graph bar shows the average mean gene expression fold ch...

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التفاصيل البيبلوغرافية
المؤلف الرئيسي:	Shinichiro Horiuchi (17800001) (author)
مؤلفون آخرون:	Nanae Koda (20469136) (author), Yui Ikeda (20469139) (author), Yuto Tanaka (11362035) (author), Yusuke Masuo (526998) (author), Yukio Kato (430483) (author), Daiju Yamazaki (3385316) (author)
منشور في:	2024
الموضوعات:	Biochemistry Medicine Cell Biology Physiology Pharmacology Cancer Science Policy Space Science Chemical Sciences not elsewhere classified investigated candidate media engineered heart tissue div >< p develop alternative approaches innocell plate increased findings may facilitate human ips cell hepatic metabolism cannot hepatic drug metabolism drug cardiotoxicity associated based microphysiological system common culture medium improved oxygenation using eht medium used hepatic metabolism improved oxygenation cardiotoxicity associated medium used may allow hepatic function also increased used commonly human liver eht cultured eht culture vitro </ typical inducers stable throughout significantly greater serious concern results suggest relaxation speed related gene nuclear receptors major cyps lowering costs evaluated using ethical concerns detected using cyp3a4 activity cyp3a4 </ cyp </ culture period contraction speed contraction length beating rate
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Induction of cytochrome P450 expression in human cryopreserved hepatocytes (cryoheps).

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