Activity-Based Protein Profiling Identifies an α‑Amylase Family Protein Contributing to the Virulence of Methicillin-Resistant Staphylococcus aureus

In search of new putative antimicrobial drug targets in methicillin-resistant Staphylococcus aureus, we aimed to identify and characterize retaining glycosidase activities in this bacterial pathogen. Using activity-based protein profiling (ABPP), a panel of 7 fluorescent probes was screened to detec...

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Bibliographic Details
Main Author:	Md Jalal Uddin (11919757) (author)
Other Authors:	Kjersti Julin (11847153) (author), Herman S. Overkleeft (128584) (author), Mona Johannessen (205726) (author), Christian S. Lentz (2880221) (author)
Published:	2025
Subjects:	Biochemistry Medicine Microbiology Pharmacology Cancer Infectious Diseases Virology Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified warranting future investigations resistant staphylococcus aureus reduced biofilm formation previously uncharacterized bgla galleria mellonella infection 7 fluorescent probes 3 biotinylated probes affect bacterial growth based protein profiling bgla ), α bacterial pathogen abpp ), vitro </ tre </ targeting α target enrichment rich media physiological relevance inhibitor studies detect activities biochemical function atl ).
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Activity-Based Protein Profiling Identifies an α‑Amylase Family Protein Contributing to the Virulence of Methicillin-Resistant Staphylococcus aureus

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