Correlation plot of the ARI values between the identified domain boundaries on the bulk count, KR-normalized, and RWS-/RWR-smoothed matrices of the hESC data.

Correlation plot of the ARI values between the identified domain boundaries on the bulk count, KR-normalized, and RWS-/RWR-smoothed matrices of the hESC data.

<p>We considered 11 kinds of matrices (“bulk”, KR-normalized, five RWS-smoothed, and four RWR-smoothed matrices) and three TAD detection methods (CaTCH, HiCseg, and TopDom).</p>

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Bibliografiske detaljer
Hovedforfatter:	Yongqi Liu (5464067) (author)
Andre forfattere:	Shili Lin (25251) (author)
Udgivet:	2025
Fag:	Medicine Genetics Biotechnology Developmental Biology Cancer Plant Biology Biological Sciences not elsewhere classified Mathematical Sciences not elsewhere classified Chemical Sciences not elsewhere classified topologically associated domains taking correct identification optimal parameter values dimensional hierarchical structure extensive analytical analyses downstream tad analyses current study provides achieve good performance xlink "> hi single cell hi real data applications assessment </ p answer biological questions based approaches prior data quality improvement performing random walks including random walk performing analyses biological questions data quality random walks simulation study performance success little improvement based approaches random walking random walk unrealistic scenario routinely generated range interactions practical guidelines necessary step little justification limited number end point empirical investigation developed accordingly chromosome three cautionary note better understanding &# 8220
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