Gene mapping, mass spectrometry, and purification of the wild-type and p.R163C mutant of human αB-crystallin.

(A) Schematic representation of the pET-28b(+) plasmid harboring the cDNA of human αB-crystallin with the p.R163C mutation, introduced via site-directed mutagenesis. (B) ESI-QTOF mass spectrometry analysis of purified human αB-crystallin, with spectra a...

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Հիմնական հեղինակ:	Aref Baharvand (21713886) (author)
Այլ հեղինակներ:	Zamara Mariam (21713889) (author), Mohammad Bagher Shahsavani (12488135) (author), Leila Rezaei Somee (21713892) (author), Issa Zarei (12742159) (author), Massoud Amanlou (3825850) (author), Giuseppe Deganutti (2609257) (author), Ali Akbar Saboury (7418342) (author), Ali Akbar Moosavi-Movahedi (313649) (author), Reza Yousefi (3125688) (author)
Հրապարակվել է:	2025
Խորագրեր:	Biophysics Biochemistry Genetics Molecular Biology Neuroscience Evolutionary Biology Developmental Biology Cancer Infectious Diseases Virology Physical Sciences not elsewhere classified potentially causing cytotoxicity monomer units within form larger oligomers enzymatic digestion increases cysteine likely impacts could also lead cardiac muscle proteins human &# 945 protein &# 8217 mutant protein decrease increased chaperone activity crystallin </ p r163c mutated protein &# 945 mutated protein mutant protein apoptotic protein used spectroscopic tertiary structures terminal domain slight increase position 163 microscopic techniques may protect functional modifications dilated cardiomyopathy dcm ). conserved arginine comprehensive investigation cell death
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Gene mapping, mass spectrometry, and purification of the wild-type and p.R163C mutant of human αB-crystallin.

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