The treatment of RSK inhibitors attenuates ORF45-increased ability of cell migration.

The treatment of RSK inhibitors attenuates ORF45-increased ability of cell migration.

<p>GFP-ORF45-overexpressing HEK293 cells (A), iSLK.Bac16 cells or iSLK.STOP45 cells undergoing Dox + NaB-induced lytic reactivation (B) and HEK293 cells infected with Bac16 or STOP45 virions (MOI = 10) (C) were subjected to a wound healing scratch assay in presence of DMSO, 10 μM BI-D1870 or 1...

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Xehetasun bibliografikoak
Egile nagusia:	Xiaojuan Li (351842) (author)
Beste egile batzuk:	Li Quan (177024) (author), Rihong Zhou (22676690) (author), Xiangpeng Liu (17898881) (author), Ronit Sarid (186795) (author), Ersheng Kuang (129028) (author)
Argitaratua:	2025
Gaiak:	Microbiology Cell Biology Molecular Biology Biotechnology Immunology Developmental Biology Cancer Infectious Diseases Virology s2152a knockin abolish primary effusion lymphoma multicentric castleman disease kaposi &# 8217 mediated viral infection infected adherent cells differentiated b cells sequential cell detachment mediated kshv transmission kshv lytic replication adherent cells lytic replication viral transmission kshv transmission cell detachment b lymphocytes lytic cycle cell transmission taken together results demonstrated radically support natural donors key role key regulator etiological agent dependent manner cell contact cell adhesion associated herpesvirus
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Antzeko izenburuak

ORF45 reduces cell adhesion through RSK activation.
nork: Xiaojuan Li (351842)
Argitaratua: (2025)

Filamin A phosphorylation is induced by ORF45-mediated RSK activation.
nork: Xiaojuan Li (351842)
Argitaratua: (2025)

RSK inhibitors suppress ORF45-induced Filamin A phosphorylation.
nork: Xiaojuan Li (351842)
Argitaratua: (2025)

ORF45 promotes cell migration during early primary infection.
nork: Xiaojuan Li (351842)
Argitaratua: (2025)

Filamin A phosphorylation is essential for ORF45-induced detachment and migration but not for virion production.
nork: Xiaojuan Li (351842)
Argitaratua: (2025)

Filamin A KO and S2152A KI reduce cell migration under ORF45 overexpression or during KSHV de novo infection or lytic reactivation.
nork: Xiaojuan Li (351842)
Argitaratua: (2025)

Filamin A KO and S2152A KI reduce KSHV de novo infection and cell-contact mediated viral infection.
nork: Xiaojuan Li (351842)
Argitaratua: (2025)

Filamin A KO and S2152A KI reduce KSHV de novo infection of cell-free virions.
nork: Xiaojuan Li (351842)
Argitaratua: (2025)

The expression levels of Filamin A in KSHV-positive cells.
nork: Xiaojuan Li (351842)
Argitaratua: (2025)

Filamin A KO and S2152A KI in donor cells do not affect KSHV cell-to-cell viral transmission.
nork: Xiaojuan Li (351842)
Argitaratua: (2025)

Filamin A KO or S2152A KI does not affect KSHV lytic reactivation.
nork: Xiaojuan Li (351842)
Argitaratua: (2025)

Validation of Filamin A KO and S2152A KI stable HEK293-mcherry cells.
nork: Xiaojuan Li (351842)
Argitaratua: (2025)

Extended Data Figure 4 – Source Data (sEPSC properties after sub-chronic ketamine)
nork: Jinseon Yu (22598699)
Argitaratua: (2025)

Table 1_Dynamics of Vibrio ostreicida in Mytilus galloprovincialis through in vivo infections.docx
nork: Martina Leonessi (22686236)
Argitaratua: (2025)

Figure 2 – Source Data (spontaneous synaptic transmission and intrinsic properties in dmPFC L2/3 neurons)
nork: Jinseon Yu (22598699)
Argitaratua: (2025)

Maximum clade credibility (MCC) trees of phylodynamic models for transmission in farm A.
nork: Marina Meester (11765542)
Argitaratua: (2025)

Output of phylodynamic (BD) and SEIR model to estimate the effective reproduction number of between-pen transmission (between-pen R<sub>e</sub>) for farm B, compartment 2 during weeks 7 to 16 of batch B.
nork: Marina Meester (11765542)
Argitaratua: (2025)

Infection dynamics and phylogenetics of HEV in two farms.
nork: Marina Meester (11765542)
Argitaratua: (2025)

Schematic overview of a pig farm and the three hypothesized environmental transmission routes (indicated by pink arrows) of hepatitis E virus in farms.
nork: Marina Meester (11765542)
Argitaratua: (2025)

The simulation parameters.
nork: Ziyang Xing (22683634)
Argitaratua: (2025)

Convergence normalization comparison.
nork: Ziyang Xing (22683634)
Argitaratua: (2025)

Throughput normalization comparison of several algorithms under different transmission conditions.
nork: Ziyang Xing (22683634)
Argitaratua: (2025)

Principle of expert library reinforcement learning designed.
nork: Ziyang Xing (22683634)
Argitaratua: (2025)

Data transmission scenario diagram in integrated network.
nork: Ziyang Xing (22683634)
Argitaratua: (2025)

Supplementary data: Adherence, treatment utilization, clinical and economic outcomes of patients with sickle cell disease with recurrent vaso-occlusive crises treated with recently approved chronic therapies in the US
nork: Chuka Udeze (22674655)
Argitaratua: (2025)

Effectiveness of HIV testing campaigns and community perceptions.
nork: Frederick Nchang Cho (14485735)
Argitaratua: (2025)

Self-reported practices towards and motivations for HIV testing among youth.
nork: Frederick Nchang Cho (14485735)
Argitaratua: (2025)

Attitudes and perceptions of HIV testing among youth.
nork: Frederick Nchang Cho (14485735)
Argitaratua: (2025)

Knowledge and awareness of HIV and testing services (n = 75).
nork: Frederick Nchang Cho (14485735)
Argitaratua: (2025)

Sociodemographic characteristics of FGD participants (n = 75).
nork: Frederick Nchang Cho (14485735)
Argitaratua: (2025)

Summary of key themes and subthemes.
nork: Frederick Nchang Cho (14485735)
Argitaratua: (2025)

Improvements to existing awareness and testing efforts.
nork: Frederick Nchang Cho (14485735)
Argitaratua: (2025)

Factors discouraging HIV testing.
nork: Frederick Nchang Cho (14485735)
Argitaratua: (2025)

Stages in the FGD process.
nork: Frederick Nchang Cho (14485735)
Argitaratua: (2025)

FGD dataset minimal anonymised.
nork: Frederick Nchang Cho (14485735)
Argitaratua: (2025)

Airborne Spread of SARS-CoV-2 Between Rooms in a Sealed, Mechanically Ventilated Ward: Evidence from a Hospital Outbreak Investigation
nork: Yo Ishigaki (11052900)
Argitaratua: (2025)

Global transcriptional reprogramming by cytomegalovirus infection suppresses MHC class II antigen presentation while enhancing migration machinery in murine dendritic cells
nork: Rhys H Parry (22367851)
Argitaratua: (2025)

Data Sheet 2_Beyond prescriptions: chronic medication adherence predicts mortality risk in a large-scale cohort study.pdf
nork: Jessica Hamuy Blanco (17279713)
Argitaratua: (2025)

Data Sheet 1_Beyond prescriptions: chronic medication adherence predicts mortality risk in a large-scale cohort study.pdf
nork: Jessica Hamuy Blanco (17279713)
Argitaratua: (2025)

Kinetic parameters for <i>S. coelicolor</i> NagS and NagA.
nork: Chao Li (145513)
Argitaratua: (2025)

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