Multi Ig-domains Intrachain pseudo quaternary interfaces.

Multi Ig-domains Intrachain pseudo quaternary interfaces.

<p><b>A-B) Tandem IgV domains in human CD226 (DNAM-1)</b>. (PDBid 6ISB) The two IgV domains in tandem with a long linker form an antiparallel interface involving a (tertiary) antiparallel strand zipper between IgV1 (strand A’) and IgV2 (strand C’) as well as a few residues in the G...

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Main Author: Caesar Tawfeeq (21087272) (author)
Other Authors: Jiyao Wang (2121157) (author), Umesh Khaniya (8822018) (author), Thomas Madej (185877) (author), James Song (4570324) (author), Ravinder Abrol (1425607) (author), Philippe Youkharibache (266279) (author)
Published: 2025
Subjects:
Biophysics
Biochemistry
Cell Biology
Genetics
Biotechnology
Immunology
Developmental Biology
Infectious Diseases
Virology
Biological Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
Physical Sciences not elsewhere classified
protein engineering around
protein coding regions
accurate machine learning
numbering scheme powers
molecular interaction systems
current estimates ranging
div >< p
domain variants constituting
systematically recognize ig
extended ” architecture
common structural signature
like domain variants
robust fold detection
interactomes </ p
ig structural proteomes
structural variants
systems </
domain sharing
scheme provides
current databases
structural proteomes
comparative structural
extended domains
“ ig
ig interactomes
wide spectrum
vascular system
systematic annotation
straightforward based
sheds light
remarkable property
reliably fold
populous fold
poorly annotated
particular jelly
nervous system
muscular system
much higher
labeling mechanism
key elements
immune system
human genome
evolutionary analyses
diverse topologies
classified today
cell recognition
algorithm implemented
>&# 8220
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