Stochastic trajectories at cell and tissue scale.

<p>The inferred-theoretical wild-type (ITWT) system shows excellent agreement with various experimentally observed characteristics of ICM cell specification. All simulations start with all cells in the undifferentiated (UND) state, having well-balanced cellular resources, before committing exc...

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التفاصيل البيبلوغرافية
المؤلف الرئيسي:	Michael Alexander Ramirez Sierra (20209354) (author)
مؤلفون آخرون:	Thomas R. Sokolowski (20209357) (author)
منشور في:	2024
الموضوعات:	Cell Biology Genetics Developmental Biology Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified Information Systems not elsewhere classified xlink "> understanding specific time window providing quantitative predictions identify parameter sets enabling lineage proportions early mammalian development biophysically realistic fashion intracellular initial conditions driven simulation techniques reproducible icm patterning pre lineage proportions level differentiation arises intracellular gene expression inner cell mass ensures correct epi type icm systems stochastic simulation framework stochastic systems necessary conditions high gene expression heterogeneity stochastic description powered simulation icm specification icm exhibits work offers surprising role seemingly cell robust unfolding remains robust reducing fate purely cell proportioning errors primitive endoderm mouse embryogenesis intercellular signaling inherent stochasticity future exploration fgf4 signaling fate proportioning fate decisions exogenous fgf4 efficiently simulating developmental biology combined action central challenge blastocyst stage based inference autonomous system autonomous mechanisms also provides advancing event adjusted based achieve robust
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Stochastic trajectories at cell and tissue scale.

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