Dendrogram of structural relatedness for 51 human GPCRs including MT1/MT2.

<p>FASTA protein sequences for 51 randomly sampled GPCRs were structurally predicted using AlphaFold2 and compared using Dali All Against All. MT1/MT2 outlined in red. Color boxes denote GPCR class: Class A/Rhodopsin (blue), Class B/Secretin (red), Class C/Glutamate (yellow), Class F/Frizzled/...

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التفاصيل البيبلوغرافية
المؤلف الرئيسي:	Cathryn S. D. Maienza (20629929) (author)
مؤلفون آخرون:	Guillaume Lamoureux (1630906) (author), Kwangwon Lee (78361) (author)
منشور في:	2025
الموضوعات:	Biophysics Biochemistry Cell Biology Molecular Biology Developmental Biology Science Policy Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified shares structural similarities experimental validation confirmed diverse biological functions div >< p derived g protein strong candidate gene knowledge gap remains concept study underscores identifying melatonin receptors human melatonin receptors neurospora crassa </ crassa </ promising candidate candidate genes n </ melatonin signaling potential receptors wake cycle ubiquitously present species comparison significant interest sequence similarity related receptor particularly due model system model organism living organisms growing need fully elucidating first step circadian research circadian clocks cells results broader applicability approach led
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Dendrogram of structural relatedness for 51 human GPCRs including MT1/MT2.

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