Image 5_Exploratory spatial transcriptomic profiling of peritumoral Th2 immune polarization in HPV-positive oropharyngeal cancer.jpeg

Image 5_Exploratory spatial transcriptomic profiling of peritumoral Th2 immune polarization in HPV-positive oropharyngeal cancer.jpeg

Introduction<p>Oropharyngeal squamous cell carcinoma (OPC) associated with high-risk human papillomavirus (HPV), particularly HPV-16, generally shows favorable outcomes yet paradoxically exhibits a high incidence of early lymphatic metastasis. The immune mechanisms underlying this phenomenon r...

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Bibliographic Details
Main Author: Naohiro Wakisaka (407153) (author)
Other Authors: Makiko Moriyama-Kita (833101) (author), Satoru Kondo (407152) (author), Eiji Kobayashi (107710) (author), Takayoshi Ueno (457816) (author), Yosuke Nakanishi (407151) (author), Kazuhira Endo (407155) (author), Hisashi Sugimoto (2146888) (author), Tomokazu Yoshizaki (407160) (author)
Published: 2025
Subjects:
Oncology and Carcinogenesis not elsewhere classified
HPV-positive oropharyngeal cancer
palatine tonsil
spatial transcriptomics
tumor immune microenvironment
Th2 immunity
lymphatic metastasis
eosinophils and mast cells
estrogen signaling
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