Differential Effects of Confinement on the Dynamics of Normal and Tumor-Derived Pancreatic Ductal Organoids

Differential Effects of Confinement on the Dynamics of Normal and Tumor-Derived Pancreatic Ductal Organoids

Pancreatic ductal adenocarcinoma (PDAC) is a cancer of the epithelia comprising the ductal network of the pancreas. During disease progression, PDAC tumors recruit fibroblasts that promote fibrosis, increasing local tissue stiffness and subjecting epithelial cells to increased compressive forces. Pr...

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Bibliographic Details
Main Author: Jonah M. Rosas (20315139) (author)
Other Authors: Joseph P. Campanale (20315142) (author), Jacob L. Harwood (20315145) (author), Lufei Li (20315148) (author), Rachel Bae (14058403) (author), Shujun Cheng (534350) (author), Julia M. Tsou (20315151) (author), Kathi M. Kaiser (20315154) (author), Dannielle D. Engle (14918157) (author), Denise J. Montell (14871338) (author), Angela A. Pitenis (7496078) (author)
Published: 2024
Subjects:
Biophysics
Biochemistry
Medicine
Cell Biology
Genetics
Biotechnology
Developmental Biology
Cancer
Chemical Sciences not elsewhere classified
Physical Sciences not elsewhere classified
subjecting epithelial cells
may shed light
healthy cells within
collective force generation
48 h within
two distinct modes
increased compressive forces
derived ductal epithelia
confined conditions exhibited
composite 3d environment
whereas normal organoids
tumor organoids exhibited
confined conditions
epithelia comprising
ductal network
tumor organoids
normal organoids
3d organoids
yield stress
vitro studies
pure matrigel
promote fibrosis
organoid expansion
mutual interactions
matrigel mixed
locally overcome
documented cytoskeletal
disease progression
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