Differential Effects of Confinement on the Dynamics of Normal and Tumor-Derived Pancreatic Ductal Organoids

Pancreatic ductal adenocarcinoma (PDAC) is a cancer of the epithelia comprising the ductal network of the pancreas. During disease progression, PDAC tumors recruit fibroblasts that promote fibrosis, increasing local tissue stiffness and subjecting epithelial cells to increased compressive forces. Pr...

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Bibliographic Details
Main Author:	Jonah M. Rosas (20315139) (author)
Other Authors:	Joseph P. Campanale (20315142) (author), Jacob L. Harwood (20315145) (author), Lufei Li (20315148) (author), Rachel Bae (14058403) (author), Shujun Cheng (534350) (author), Julia M. Tsou (20315151) (author), Kathi M. Kaiser (20315154) (author), Dannielle D. Engle (14918157) (author), Denise J. Montell (14871338) (author), Angela A. Pitenis (7496078) (author)
Published:	2024
Subjects:	Biophysics Biochemistry Medicine Cell Biology Genetics Biotechnology Developmental Biology Cancer Chemical Sciences not elsewhere classified Physical Sciences not elsewhere classified subjecting epithelial cells may shed light healthy cells within collective force generation 48 h within two distinct modes increased compressive forces derived ductal epithelia confined conditions exhibited composite 3d environment whereas normal organoids tumor organoids exhibited confined conditions epithelia comprising ductal network tumor organoids normal organoids 3d organoids yield stress vitro studies pure matrigel promote fibrosis organoid expansion mutual interactions matrigel mixed locally overcome documented cytoskeletal disease progression
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Differential Effects of Confinement on the Dynamics of Normal and Tumor-Derived Pancreatic Ductal Organoids

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