Figure 4 from M4205 (IDRX-42) Is a Highly Selective and Potent Inhibitor of Relevant Oncogenic Driver and Resistance Variants of KIT in Cancer

Figure 4 from M4205 (IDRX-42) Is a Highly Selective and Potent Inhibitor of Relevant Oncogenic Driver and Resistance Variants of KIT in Cancer

<p>Dose- and exposure-dependent inhibition of KIT autophosphorylation with M4205 in the GIST430/654 model. <b>A,</b> Tumor-bearing mice were treated daily with three different doses of M4205 for 5 days, and inhibition of KIT autophosphorylation compared with untreated controls was...

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Bibliographische Detailangaben
1. Verfasser: Christina Esdar (16424072) (author)
Weitere Verfasser: Nina Linde (16424066) (author), Andreas Blum (21644608) (author), Hanno Schieferstein (21644611) (author), Christine Drechsler (16424069) (author), Eva Sherbetjian (21644614) (author), Carl Petersson (21644617) (author), Edith Ross (21644620) (author), Birgitta Leuthner (17885856) (author), Ulrich Grädler (21644623) (author), Dieter Dorsch (21644626) (author), Andree Blaukat (15088980) (author)
Veröffentlicht: 2025
Schlagworte:
Cancer
Cancer Biology
Therapeutic Research and Development
Oncogenes & Tumor Suppressors
Oncogenes
Sarcomas
Small Molecule Agents
Kinase inhibitors
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