$Vpr expression results in an increased fraction cells with TCM-like phenotype (CD45RA-CCR7+).$

Vpr expression results in an increased fraction cells with TCM-like phenotype (CD45RA-CCR7+).

A-B) Representative quantification of percentage of cells in each of four memory compartments as defined by CD45RA and CCR7 surface marker expression in CD4+ T cells infected with A) HIV-GFP or HIV-GFP-Vpr (n = 6) or B) mCherry or Vpr-mCherry lentiv...

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Bibliographische Detailangaben
1. Verfasser:	Catherine A. Lewis (22177707) (author)
Weitere Verfasser:	David M. Margolis (244046) (author), Edward P. Browne (8913893) (author)
Veröffentlicht:	2025
Schlagworte:	Cell Biology Molecular Biology Biotechnology Immunology Developmental Biology Cancer Infectious Diseases Virology vorinostat potently enhances viral factors shape viral factors interact sup >+</ sup specific viral factors div >< p critical cellular factors 1 reporter strains 1 accessory proteins 1 accessory protein reservoir formation selects preventing reservoir formation regulate latency establishment 1 latency results 1 latency establishment prevents hiv transmission cure hiv infection vpr &# 8217 latent viral reservoir 1 protein vpr whether hdacs interact cell latency model host cell factors promoting hiv expression central memory cd4 latent reservoir central memory 1 entry vpr expression new latency cell subtypes cell death latent proviruses single hiv individual hiv allow hiv vpr possesses vpr plays significant increase recently shown promoting activity primary cd4 mediated restriction induced apoptosis histone deacetylases findings suggest dramatically improved clinical prognosis binding domain antiretroviral therapy
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Vpr expression results in an increased fraction cells with T<sub>CM</sub>-like phenotype (CD45RA<sup>-</sup>CCR7<sup>+</sup>).

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