Ca<sup>+2</sup>-mediated electrostatic interactions between CD163 subunits in the CD163/Hp(1–1)Hb complex.

Ca<sup>+2</sup>-mediated electrostatic interactions between CD163 subunits in the CD163/Hp(1–1)Hb complex.

<p><b>(A)</b> Ca<sup>+2</sup>-dependent reciprocal electrostatic pairings between D7 and D9 of CD163 subunits. Key residues involved in the interactions and Ca<sup>+2</sup> ions bound to the acidic clusters in these interfaces are shown as sticks and spheres...

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書目詳細資料
主要作者:	Ching-Shin Huang (21703202) (author)
其他作者:	Hui Wang (30400) (author), Joshua B. R. White (14254170) (author), Oksana Degtjarik (2810629) (author), Cindy Huynh (2697772) (author), Kristoffer Brannstrom (21703205) (author), Mark T. Horn (21703208) (author), Stephen P. Muench (236881) (author), William S. Somers (2659714) (author), Javier Chaparro-Riggers (15013755) (author), Laura Lin (2272402) (author), Lidia Mosyak (1635880) (author)
出版:	2025
主題:	Biophysics Biochemistry Cell Biology Molecular Biology Pharmacology Immunology Cancer Space Science Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified renal tissues due haptoglobin &# 8211 circulating haptoglobin acts bound receptor assemblies electron microscopy structures composite binding site 1 binding stoichiometry cd163 scavenger receptor cd163 remains unclear molecular mechanism underlying hemoglobin clearance mechanism ligand binding site molecular mechanism structures reveal human cd163 cd163 functions unliganded state study elucidates structural elucidation primary defense oxidative nature one protomer mostly well free hemoglobin damage vascular autoinhibitory configuration also form
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