Overview of the study.

<p>We obtained tumor mutations from TCGA and AACR GENIE datasets. Then, we applied Fisher’s Exact Test followed by Benjamini-Hochberg multiple corrections. After obtaining 3424 significant mutation pairs, we mapped their components to pathways and tissues for functional interpretation. This he...

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Bibliographic Details
Main Author:	Bengi Ruken Yavuz (21983004) (author)
Other Authors:	Ugur Sahin (133198) (author), Hyunbum Jang (70508) (author), Ruth Nussinov (10169) (author), Nurcan Tuncbag (3173064) (author)
Published:	2025
Subjects:	Medicine Genetics Pharmacology Cancer Plant Biology Biological Sciences not elsewhere classified Information Systems not elsewhere classified provide metastatic breast patients ’ genomes optimal drug regimen onto pathways indicates intratumor mutational diversity usefully reveals markers 000 tumor sequences uncover metastatic mutations tumor mutational profiles novel computational framework detecting metastasis based detect 3424 co div >< p tumor signaling existing tumor cancer profiles cancer markers targeting resource synthetic lethality specific mutations oncogenic mutations molecular basis mechanistic basis invaluable metastasis induced senescence genome level forecasting resistance exist </ excluded </ effective identification discover mutations different oncoproteins detect metastases date investigated
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Overview of the study.

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