The morphine-induced increase of reactive/surveillant microglial ratio, microglial cell density, and microglial phagocytic structures was fully normalized by the administration of NAC, ibudilast, and the combined administration of both drugs (NAC + ibudilast).

مواد مشابهة

• The significant increase in astrocytic density and astrocyte activation observed in the hippocampus of rats consuming morphine for fifty-six days was reduced by the administration of NAC, ibudilast, and the combined administration of both drugs (NAC + ibudilast).
  حسب: María Elena Quintanilla (8068691)
  منشور في: (2024)
• The co-administration of NAC (40 mg/kg/day, i.p.) and ibudilast (7.5 mg/kg/day, i.p.) leads to a greater reduction in chronic morphine intake compared to separate administration of both drugs.
  حسب: María Elena Quintanilla (8068691)
  منشور في: (2024)
• The significant increase in oxidative stress observed in the hippocampus of rats that had been consuming morphine for fifty-six days was effectively mitigated by the separate administration of NAC (40 mg/kg/day, i.p.) and ibudilast (7.5 mg/kg/day, i.p.), as well as by their co-administration for four days.
  حسب: María Elena Quintanilla (8068691)
  منشور في: (2024)
• The significant decrease in GLT-1 levels observed in the nucleus accumbens of rats that had consumed morphine for fifty-six days was completely reversed by the co-administration of NAC (40 mg/kg/day, i.p.) and ibudilast (7.5 mg/kg/day, i.p.).
  حسب: María Elena Quintanilla (8068691)
  منشور في: (2024)
• The administration of NAC (40 mg/kg per day, i.p.) and ibudilast (7.5 mg/kg per day, i.p.) alone, as well as their co-administration for four days, significantly increased water intake in rats that had been consuming morphine for fifty-six days, without affecting total fluid intake or body weight.
  حسب: María Elena Quintanilla (8068691)
  منشور في: (2024)