Figure 6 from DIPG Harbors Alterations Targetable by MEK Inhibitors, with Acquired Resistance Mechanisms Overcome by Combinatorial Inhibition

Figure 6 from DIPG Harbors Alterations Targetable by MEK Inhibitors, with Acquired Resistance Mechanisms Overcome by Combinatorial Inhibition

<p>Synergy of combined dasatinib and trametinib in BRAF<sup>G469V</sup>-driven DIPG cells. <b>A,</b> Cell viability matrices for ICR-B169 parental (gray) and trametinib-resistant clones T1 (<i>MEK2</i><sup>I115N</sup>, pink), (T3 <i>MEK1<...

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Бібліографічні деталі
Автор:	Elisa Izquierdo (15110795) (author)
Інші автори:	Diana M. Carvalho (5608127) (author), Alan Mackay (20972) (author), Sara Temelso (13755357) (author), Jessica K.R. Boult (14936256) (author), Giulia Pericoli (15121517) (author), Elisabet Fernandez (15121520) (author), Molina Das (15121523) (author), Valeria Molinari (15110798) (author), Yura Grabovska (14234303) (author), Rebecca F. Rogers (14941192) (author), Maria Antonietta Ajmone-Cat (15121526) (author), Paula Z. Proszek (14997741) (author), Mark Stubbs (1353564) (author), Sarita Depani (15121529) (author), Patricia O'Hare (15121532) (author), Lu Yu (14946738) (author), Georgia Roumelioti (15121535) (author), Jyoti S. Choudhary (9927836) (author), Matthew Clarke (3550808) (author), Amy R. Fairchild (15110801) (author), Thomas S. Jacques (15117937) (author), Richard G. Grundy (15018659) (author), Lisa Howell (15121538) (author), Susan Picton (3813571) (author), Jenny Adamski (11420832) (author), Shaun Wilson (5013728) (author), Juliet C. Gray (15121541) (author), Bassel Zebian (5986940) (author), Lynley V. Marshall (15110912) (author), Fernando Carceller (14945229) (author), Jacques Grill (15015216) (author), Maria Vinci (15121544) (author), Simon P. Robinson (14934318) (author), Michael Hubank (15104113) (author), Darren Hargrave (15016889) (author), Chris Jones (25458) (author)
Опубліковано:	2025
Предмети:	Cancer Therapeutic Research and Development CNS Cancers Gliomas, Glioblastomas Pediatric Cancers Small Molecule Agents Kinase inhibitors Translational Research
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