Expression of IFNα and IFNβ in HAND brains.

<p>IFNα (A), IFNβ (B), OAS2 (D), and IFIT2 (E) mRNA expression was analyzed by ddRT-qPCR in the WM of HAND brains (n = 14), compared with WM of HIV- control brain samples (n = 6) or HIV+HAND- brains (n = 7). The p-value was calculated by a Krukal-Wallis Test in comparison with controls. The me...

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Glavni avtor:	Yuyang Tang (124043) (author)
Drugi avtorji:	Ling Xie (2026981) (author), Ciniso Sylvester Shabangu (18236013) (author), Dajiang Li (3819199) (author), Gabriela da Silva Prates (15229642) (author), Ashokkumar Manickam (22097256) (author), Lilly M. Wong (12221774) (author), Antoine Chaillon (309416) (author), Edward P. Browne (8913893) (author), Sara Gianella (196115) (author), Wenzhe Ho (332788) (author), David M. Margolis (244046) (author), Xian Chen (107385) (author), Wenhui Hu (80326) (author), Guochun Jiang (777612) (author)
Izdano:	2025
Teme:	Biophysics Cell Biology Genetics Molecular Biology Neuroscience Physiology Immunology Developmental Biology Cancer Mental Health Infectious Diseases Biological Sciences not elsewhere classified present &# 8212 last gift cohort increased &# 8212 human endogenous retrovirus cell rna sequencing 7 %&# 8212 associated neurocognitive disorders also highly active happen without hiv brain tissues collected brain organoid model acute hiv infection immune response pathways glial cells even interferon signaling within remains active endothelial cells cognitive disorders xlink "> using single unrelated mechanisms rapid autopsies protein profiles negative controls molecular mechanism may contribute hand ), findings point especially strong directly trigger better understand antiretroviral therapy 9 hand 27 brains
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Expression of IFNα and IFNβ in HAND brains.

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