Inferred phylogenies for CSC28.

<div><p>Motivation</p><p>DNA sequencing of multiple bulk samples from a tumor provides the opportunity to investigate tumor heterogeneity and reconstruct a phylogeny of a patient’s cancer. However, since bulk DNA sequencing of tumor tissue measures thousands of cells from a h...

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التفاصيل البيبلوغرافية
المؤلف الرئيسي:	Henri Schmidt (17364844) (author)
مؤلفون آخرون:	Benjamin J. Raphael (12706324) (author)
منشور في:	2024
الموضوعات:	Genetics Evolutionary Biology Cancer Biological Sciences not elsewhere classified Mathematical Sciences not elsewhere classified Information Systems not elsewhere classified observed mutational frequencies matrices appearing within many existing methods lower distortion compared infers mutation phylogenies patient &# 8217 investigate tumor heterogeneity bulk sequencing data challenging computational problem outperforms existing approaches multiple bulk samples structured regression problem thousand distinct sub phylogenetic reconstruction directly regression based approach tumors </ p reconstruct phylogenetic trees regression sub distinct sub phylogenetic reconstruction two patient tumor provides fastbe </ reconstruction problem simulated data real data reconstruction accuracy accurate reconstruction two parts tree space simple method sample efficiency phylogenetic inference ninety samples linear programming less violation large datasets heterogeneous mixture fourteen b fixed tree fewer violations empirical improvements combinatorial structure better agreement art approaches ancestral relationships
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Inferred phylogenies for CSC28.

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