Human tau misfolding and calcium influx changes in differentiated SH-SY5Y cells inoculated with AD brain-derived tau.

(A) Fluo-8 fluorescence expressed as ΔF/F0 for controls (medium and OND) and cultures inoculated with AD brain-derived tau (n = 6) for 3 days. We captured confocal time-lapse images: 90 frames for baseline Fluo-8 fluorescence in 2 s intervals and 21...

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المؤلف الرئيسي:	Lenka Hromadkova (4320787) (author)
مؤلفون آخرون:	Chae Kim (147292) (author), Tracy Haldiman (147295) (author), Mohammad Khursheed Siddiqi (2917649) (author), Krystyna Surewicz (147299) (author), Kiley Urquhart (21540155) (author), Dur-E-Nayab Sadruddin (21540158) (author), Lihua Peng (2285215) (author), Xiongwei Zhu (21077) (author), Witold K. Surewicz (147331) (author), Mark L. Cohen (16916684) (author), Mark R. Chance (196040) (author), Rohan de Silva (444885) (author), Janna Kiselar (1346883) (author), Jiri G. Safar (10987176) (author)
منشور في:	2025
الموضوعات:	Biophysics Biochemistry Neuroscience Infectious Diseases Biological Sciences not elsewhere classified Physical Sciences not elsewhere classified neuronally differentiated sh labeled monoclonal antibodies different pathogenetic steps pathogenic tau conformers derived tau conformers calcium influx induced alzheimer &# 8217 individual structural variability div >< p misfolded tau proteins derived tau protein variable synaptic toxicity like templated propagation different progression rates high seeding potency tau protein misfolding disease </ p misfolded ad brain tau protein misfolded tau seeding potency tau misfolding vitro </ calcium homeostasis alzheimer ’ structural organization structural exposure seeding assays rapid progression progression rate different mtbds underlying mechanism terminal tails sy5y cells significant driver r4 ). r1 domain propagation rate neuronal cultures major driver major diversity leading indicators fourth mtbd extensive inter distinct domains considered prion cognitive decline ad ),
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Human tau misfolding and calcium influx changes in differentiated SH-SY5Y cells inoculated with AD brain-derived tau.

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