Development of Galectin-7-Specific Nanobodies: Implications for Immunotherapy and Molecular Imaging in Cancer

Galectins play significant roles in regulating immune responses, posing challenges for cancer immunotherapy. The development of galectin inhibitors has been limited by their high structural homology and the lack of noninvasive imaging tools to identify potential responsive patients. We developed 12...

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المؤلف الرئيسي:	Rita Nehmé (21072212) (author)
مؤلفون آخرون:	Marlène Fortier (13008071) (author), Myriam Létourneau (8355765) (author), Camille Fuselier (10221707) (author), Philippine Granger Joly de Boissel (13008074) (author), Alyssa Dumoulin (21072215) (author), Brigitte Guérin (1754623) (author), Véronique Dumulon-Perreault (2325331) (author), Samia Ait-Mohand (1754617) (author), Otman Sarrhini (5704991) (author), Sacha T. Larda (7330730) (author), Yarileny Castellanos Villamizar (21072218) (author), Mighel Bernier (21072221) (author), Natalia Porębska (21072224) (author), Łukasz Opaliński (21072227) (author), David Chatenet (1585321) (author), Nicolas Doucet (111644) (author), Yves St-Pierre (23432) (author)
منشور في:	2025
الموضوعات:	Biochemistry Medicine Cell Biology Immunology Developmental Biology Cancer Infectious Diseases regulating immune responses providing novel tools investigating immune regulation high structural homology cu ] cu 20 h (< negative breast cancer 64 ([< sup reduced subsequent apoptosis noninvasive imaging tools 64 </ sup enable pet imaging enhancing cancer immunotherapy developed 12 galectin pet imaging cancer immunotherapy [< sup p </ molecular imaging developed galectin cell apoptosis specific nanobodies posing challenges mouse model lead nb galectins tested galectin inhibitors cell glycoreceptors binding activity 001 ).
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Development of Galectin-7-Specific Nanobodies: Implications for Immunotherapy and Molecular Imaging in Cancer

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