Electrostatic Anchoring in RNA-Ligand DesignDissecting the Effects of Positive Charges on Affinity, Selectivity, Binding Kinetics, and Thermodynamics

Targeting RNA with small molecules is an emerging field in medicinal chemistry. However, highly potent ligands are often challenging to achieve. One intuitive strategy to enhance ligand’s potency is the implementation of positively charged moieties to interact with the negatively charged RNA phospha...

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Bibliographic Details
Main Author:	Laura Almena Rodriguez (21008567) (author)
Other Authors:	Elisabeth Kallert (13282708) (author), Jan-Åke Husmann (21008570) (author), Kirsten Schaubruch (21008573) (author), Katherina I. S. Meisel (21008576) (author), Marvin Schwickert (11415137) (author), Sabrina N. Hoba (13113182) (author), Ralf Heermann (88732) (author), Christian Kersten (9215) (author)
Published:	2025
Subjects:	Biophysics Biochemistry Molecular Biology Pharmacology Immunology Cancer Inorganic Chemistry Infectious Diseases Computational Biology Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified positively charged moieties one intuitive strategy faster association rates highly potent ligands higher charged ligands ligand design principle enhance ligand ’ structurally unrelated rna loose binding interactions binding affinity driven 1 </ sub thermodynamics targeting rna ligand interactions multibasic ligands ligand interaction binding affinity tte </ ba </ universal rna vi riboswitch small molecules positive charges often challenging medicinal chemistry itc experiments emerging field electrostatic anchors electrostatic anchoring binding kinetics
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Electrostatic Anchoring in RNA-Ligand DesignDissecting the Effects of Positive Charges on Affinity, Selectivity, Binding Kinetics, and Thermodynamics

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