Figure S1 from PARP Inhibition Induces Synthetic Lethality and Adaptive Immunity in LKB1-Mutant Lung Cancer

Figure S1 from PARP Inhibition Induces Synthetic Lethality and Adaptive Immunity in LKB1-Mutant Lung Cancer

<p>LKB1 deficiency impairs IFNγ pathway by hindering STAT1 phosphorylation. (a) Western blotting for detection of LKB1 and pAMPK expression in K and KL lung tumors. (b) UMAP of sub-clustered CD45+ immune cells from lung tumor samples of K and KL, colored by cell types. (c) The proportion of ea...

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Auteur principal: Li-Li Long (14963775) (author)
Autres auteurs: Si-Cong Ma (14963778) (author), Ze-Qin Guo (14963781) (author), Yan-Pei Zhang (14963784) (author), Zhenzhen Fan (14963787) (author), Li-Juan Liu (14963790) (author), Li Liu (12292657) (author), Duan-Duan Han (14963793) (author), Meng-Xin Leng (14963796) (author), Jian Wang (14963799) (author), Xue-Jun Guo (14963802) (author), Jia-Le Tan (14963805) (author), Xiao-Ting Cai (14963808) (author), Yan Lin (14963811) (author), Xinghua Pan (14963814) (author), De-Hua Wu (14963817) (author), Xue Bai (14963820) (author), Zhong-Yi Dong (11855458) (author)
Publié: 2025
Sujets:
Cancer
Tumor Biology
Molecular and Cellular Biology
Immuno-oncology
DNA Damage and Repair
DNA repair
Immunotherapy
Combination immunotherapy
Lung Cancer
Tumor Microenvironment
Immune cells and the microenvironment
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