Data Sheet 1_Efficacy of MLN9708 (ixazomib) in experimental autoimmune myasthenia gravis and in anti-AChR producing primary thymic cell cultures from myasthenia gravis patients.docx

Data Sheet 1_Efficacy of MLN9708 (ixazomib) in experimental autoimmune myasthenia gravis and in anti-AChR producing primary thymic cell cultures from myasthenia gravis patients.docx

<p>Proteasome inhibitors can eliminate malignant, alloreactive, or autoreactive plasma cells. These cells are key players in antibody-mediated autoimmune disorders and thus suitable therapeutic targets for these drugs. However, certain proteasome inhibitors cause toxic peripheral neuropathy in...

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Main Author: Marina Mané-Damas (11613418) (author)
Other Authors: Abhishek Saxena (6058130) (author), Gisela Nogales-Gadea (184741) (author), Jo Stevens (5291972) (author), Shannen Vincken (21364013) (author), Maarten van Beek (21364016) (author), Nynke J. van den Hoogen (21364019) (author), Elbert A. J. Joosten (21364022) (author), Nick Willcox (275138) (author), Hans Duimel (325720) (author), Jos G. Maessen (8476527) (author), Peter C. Molenaar (19822326) (author), Marc H. De Baets (21364025) (author), Mario Losen (357554) (author), Pilar Martinez-Martinez (357555) (author)
Published: 2025
Subjects:
Genetic Immunology
ixazomib
targeting autoimmune plasma cells
myasthenia gravis
proteasome inhibition
autoantibody
therapy
autoimmunity
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