Working model for the role of PPP2R1A in regulating the stability of RTA.

<p>The scaffold protein PPP2R1A interacted with RTA, inducing RTA dephosphorylation mediated by phosphatase PP2A, which seriously destroyed the transcription activity of RTA and thereby greatly inhibiting KSHV lytic replication. In turn, RTA promoted PPP2R1A degradation through ubiquitin-prote...

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Detalles Bibliográficos
Autor Principal:	Lei Bai (631944) (author)
Outros autores:	Lianghui Dong (7908431) (author), Jiazhen Dong (595963) (author), Xiaowei Liang (4721025) (author), Jiangwei Peng (21524781) (author), Yuncai Chen (7541564) (author), Xiaoyi Sun (2323519) (author), Yuting Chen (151583) (author), Xintong Li (3110796) (author), Hua Cai (15034) (author), Jing Huang (41604) (author), Zixu Cao (22772675) (author), Ke Lan (232754) (author)
Publicado:	2025
Subjects:	Biochemistry Microbiology Cell Biology Molecular Biology Evolutionary Biology Cancer Science Policy Mental Health Infectious Diseases Plant Biology Virology Biological Sciences not elsewhere classified provide new insights new binding partner human &# 947 host antiviral mechanism scaffold protein ppp2r1a promote ppp2r1a degradation initiating lytic replication kshv progeny virions viral lytic replication lytic replication ppp2r1a overexpression encoded replication viral latency transcription factor transcription activity transcription activator taken together proteasome pathway pharmacological agonist next demonstrated life cycle fully elucidated extensive studies central role
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Working model for the role of PPP2R1A in regulating the stability of RTA.

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