Engineered Alcohol Dehydrogenases-Catalyzed Enantiodivergent Atroposelective Synthesis of Axially Chiral Biaryl Phenols via Dynamic Kinetic Resolution

Engineered Alcohol Dehydrogenases-Catalyzed Enantiodivergent Atroposelective Synthesis of Axially Chiral Biaryl Phenols via Dynamic Kinetic Resolution

Axially chiral biaryl phenols are prominent motifs in natural products, bioactive compounds, chiral ligands, and catalysts, yet biocatalytic enantiodivergent synthetic routes remain rare. Herein, we report a biocatalytic dynamic kinetic resolution (DKR) strategy leveraging transient lactol/aldehyde...

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Bibliographic Details
Main Author: Jie Chen (5892) (author)
Other Authors: Xiaolong Gao (384686) (author), Zhuoting Peng (22207820) (author), Yongzhen Peng (2052658) (author), Wei He (131453) (author), Zheng Fang (727034) (author), Yujing Hu (4097848) (author), Kai Guo (54091) (author)
Published: 2025
Subjects:
Biophysics
Biochemistry
Microbiology
Molecular Biology
Pharmacology
Biotechnology
Ecology
Mental Health
Infectious Diseases
Chemical Sciences not elsewhere classified
Information Systems not elsewhere classified
practical biocatalytic method
experimental results suggest
existing chemical methodologies
engineered alcohol dehydrogenases
valuable complement
thus offering
r </
prominent motifs
natural products
highly enantioselectivity
enantiodivergent synthesis
e </
chiral ligands
catalytic efficiency
bioactive compounds
approach represents
aldehyde tautomerization
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