Phosphatidylcholine Chain-Length of Bioinspired Lipoprotein Modulates Interactions with Collagen for Intratumor Delivery in Pancreatic Cancer

Pancreatic cancer, one of the most lethal malignant tumors, is greatly challenged by poor drug delivery efficiency because of the dense and intricate desmoplastic stroma. Given the abnormal expression of scavenger receptor B type 1 (SR-B1) and the dense collagen I (COL1)-enriched extracellular matri...

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التفاصيل البيبلوغرافية
المؤلف الرئيسي:	Guodong Li (1525873) (author)
مؤلفون آخرون:	Yichen Zhang (473963) (author), Jinhua Wang (1506) (author), Yiyu Liang (21374087) (author), Yuan Zhang (41832) (author), Yifei Chi (20903754) (author), Carter Sun (21374090) (author), Zixin Hu (673180) (author), Shiyang Wu (729947) (author), Guo-Liang Lu (1941463) (author), Jingyuan Wen (9201088) (author), Zhiwen Zhang (767990) (author)
منشور في:	2025
الموضوعات:	Biophysics Medicine Pharmacology Biotechnology Cancer Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified specific tumor accumulation reduced diffusion capacity lessened tumor accumulation intricate desmoplastic stroma highest diffusion capacity lethal malignant tumors encouraging delivery platform developed four blps based blps represented effective cancer chemotherapy based ecm barrier pancreatic tumors pancreatic cancer intratumoral delivery intratumor delivery based blp system showed survival prolongation regular chain prolonging survival lowest affinity intratumor distribution increased affinity greatly challenged declined efficacy best efficacy abnormal expression
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Phosphatidylcholine Chain-Length of Bioinspired Lipoprotein Modulates Interactions with Collagen for Intratumor Delivery in Pancreatic Cancer

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