Image 1_Beyond Trikafta: new models to assess tissue dependent rescue of N1303K-CFTR.pdf

Image 1_Beyond Trikafta: new models to assess tissue dependent rescue of N1303K-CFTR.pdf

Rationale<p>Respiratory status of people with Cystic Fibrosis (pwCF) carrying N1303K is improved by Elexacaftor/Tezacaftor/Ivacaftor (ETI) but, contrary to other mutations, the impact on sweat test results is limited.</p>Methods<p>To explore this discrepancy, we implemented new swe...

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Main Author: Iwona Pranke (766362) (author)
Other Authors: Valeria Capurro (282901) (author), Benoit Chevalier (260630) (author), Emanuela Pesce (207804) (author), Valeria Tomati (6080210) (author), Cristina Pastorino (20277087) (author), Mairead Kelly-Aubert (17612307) (author), Aurelie Hatton (22518674) (author), Elise Dreano (647303) (author), Mariateresa Lena (20277090) (author), Renata Bocciardi (115174) (author), Federico Zara (176248) (author), Stefano Pantano (20277093) (author), Vito Terlizzi (5564168) (author), Cristina Lucanto (6499259) (author), Stefano Costa (3159774) (author), Laura Claut (22518677) (author), Valeria Daccò (18279170) (author), Piercarlo Poli (10454891) (author), Massimo Maschio (10798383) (author), Benedetta Fabrizzi (7474484) (author), Nicole Caporelli (7474487) (author), Marco Cipolli (7474490) (author), Sonia Volpi (22518680) (author), Frederique Chedevergne (22518683) (author), Laure Cosson (22518686) (author), Julie Macey (13540978) (author), Sophie Ramel (22518689) (author), Laurence Weiss (240247) (author), Dominique Grenet (394177) (author), Laurence Le Clainche-Viala (22518692) (author), Benoit Douvry (14113815) (author), Bruno Ravoninjatovo (12056921) (author), Camille Audousset (17837019) (author), Aurélie Tatopoulos (22518695) (author), Bénédicte Richaud-Thiriez (22518698) (author), Melissa Baravalle (22518701) (author), Guillaume Thouvenin (5126465) (author), Guillaume Labbé (22518704) (author), Marie Mittaine (7373114) (author), Philippe Reix (3829810) (author), Isabelle Durieu (512217) (author), Julie Mankikian (22518707) (author), Stéphanie Bui (11705693) (author), Thao Nguyen-Khoa (372066) (author), Karim Khoukh (22518710) (author), Clémence Martin (9392331) (author), Jennifer Da Silva (17123326) (author), Paola De Carli (22518713) (author), Carlo Castellani (724942) (author), Federico Cresta (421311) (author), Luis Galietta (14911301) (author), Anne Guillemaut (22518719) (author), Emmanuelle Girodon (240265) (author), Natacha Remus (12881192) (author), Mathis Bulcaen (22518722) (author), Marjolein Ensinck (22518725) (author), Miroslaw Zajac (17612298) (author), Marianne Carlon (22518728) (author), Jean LeBihan (22518731) (author), Pierre-Régis Burgel (113331) (author), Isabelle Sermet-Gaudelus (173646) (author), Alexandre Hinzpeter (240237) (author), Nicoletta Pedemonte (383764) (author)
Published: 2025
Subjects:
Pharmacology
cystic fibrosis
CF
CFTR (cystic fibrosis transmembrane conductance regulator)
N1303K-CFTR
sweat gland
CFTR modulator
elexacaftor/tezacaftor/ivacaftor (ETI)
airway epithelium
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