Altered localization and expression of the tight junction protein claudin-5 by iAs or Mn alone and coexposure to iAs and Mn.

<p><b>(A)</b>: Representative immunofluorescence staining of claudin-5 (green, Alexa Fluor 488) after 24h exposure: a, control; b, iAs (10 µM); c-e, Mn groups (10, 100, and 200 µM); f-h, iAs and Mn coexposure groups (iAs + Mn: 10 + 10, 100, and 200 µM). The yellow arrow indicates t...

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Bibliographic Details
Main Author:	Toshiaki Hitomi (213290) (author)
Other Authors:	Hiroko Okuda (843248) (author), Ayako Takata (7526720) (author), Hiroshi Yamauchi (71653) (author)
Published:	2025
Subjects:	Biochemistry Medicine Cell Biology Molecular Biology Physiology Immunology Developmental Biology Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified assessed tight junction tight junction injury likely additive effect antioxidant stress markers potential synergistic effect induced tj injury significant positive correlation results showed expression regarding inflammatory cytokines blood &# 8211 1 ), relative 001 ), suggesting bbb tj injury div >< p ias exposure compared synergistic effect inflammatory cytokines injury using oxidative stress neurotoxicity compared ias exposure zonula occludens vitro </ slightly higher inorganic arsenic ias alone heme oxygenase glial cells findings demonstrate dependent increase brain barrier affect ias 1 expression
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Altered localization and expression of the tight junction protein claudin-5 by iAs or Mn alone and coexposure to iAs and Mn.

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