AKB9778 increases the SC area of VEC-Y685F mutant mice.

<p>A. Schematic representing timepoints of topical ocular application of AKB9778 containing eyedrops or vehicle. B. Confocal microscopy images of VEC-WT or VEC-Y685F-KI cornea whole mounts showing the SC area (green, PECAM-1) after 4 weeks treatment with Vehicle or AKB9778 eye drops (twice dai...

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Bibliographic Details
Main Author:	Sarthak Mishra (12369590) (author)
Other Authors:	Ute Ipe (21377561) (author), Astrid F. Nottebaum (19955940) (author), Kevin G. Peters (21377564) (author), Dietmar Vestweber (92962) (author)
Published:	2025
Subjects:	Biochemistry Medicine Cell Biology Genetics Molecular Biology Neuroscience Physiology Pharmacology Evolutionary Biology Developmental Biology Virology Chemical Sciences not elsewhere classified xlink "> interference xlink "> glaucoma schlemm &# 8217 irreversible blindness worldwide hybrid vessel present high intraocular pressure draining aqueous humor ptp gene inactivation ptp also targets ko </ sup mice expressing tie2 increasing sc area ptp inhibitor akb9778 analyzed whether tie2 improving sc function sc area ptp ), aged mice adult mice sc function sc ), y685f mutation systemic circulation promising approach major substrate leading cause could show anterior part
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AKB9778 increases the SC area of VEC-Y685F mutant mice.

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