MitoTracer identified essential primary BRAF inhibitor-resistant genes.
<p>(A)The reconstructed lineage was visualized by heatmap from MitoTracer. All these cells were clustered into two major clusters labeled “Cluster_1” and “Cluster_2”. Cells were labeled according to their original BRAF inhibitor resistance status, “Resistant” and “Parental”. We also labeled th...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , , , |
| منشور في: |
2025
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| الموضوعات: | |
| الوسوم: |
إضافة وسم
لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!
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| الملخص: | <p>(A)The reconstructed lineage was visualized by heatmap from MitoTracer. All these cells were clustered into two major clusters labeled “Cluster_1” and “Cluster_2”. Cells were labeled according to their original BRAF inhibitor resistance status, “Resistant” and “Parental”. We also labeled the primary resistant cells predicted by MitoTracer with “Resistant Cells”. (B) Graphic description of positive selection for primary resistant-related MT mutation, MT_16389_G-A. (C) Gene ontology biological process enrichment results of 674 differentially expressed genes. (D) GSEA enrichment results of 674 differentially expressed genes. (E) The overall expression level across resistant and MT_16389_G-A status. We defined the group “MT0” which presented the cells with MT_16389_G-A mutation, and MT1 indicated the cells without MT_16389_G-A mutation. (F-G) the expression level of PSMB3, SNRPD2, and UBL5 across resistant and MT_16389_G-A status. The definition of the group was the same as (E). ***P < 0.0001 and **** P < 0.00001.</p> |
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